{"product_id":"egcanrna","title":"Comprehensive Tumor Profiling – RNA","description":"\u003cp\u003eComprehensive Tumor Profiling (RNA) is a next-generation sequencing (NGS)-based assay that evaluates the RNA expression profile of tumor samples to provide a deeper understanding of tumor biology. Unlike DNA-based testing, RNA profiling focuses on active gene expression, enabling detection of gene fusions, splice variants, and transcriptional changes that may not be visible at the DNA level.\u003c\/p\u003e\u003cp\u003eThis test is widely used in oncology to identify actionable biomarkers that guide targeted therapy selection, immunotherapy decisions, and clinical trial eligibility. It is particularly valuable for detecting gene fusions in solid tumors and hematologic malignancies, as well as assessing pathway activation that may influence tumor behavior and treatment response.\u003c\/p\u003e\u003cp\u003eThe results provide clinicians with a comprehensive molecular overview of the tumor, supporting precision oncology and personalized treatment strategies.\u003c\/p\u003e\u003cp\u003eClinical Applications\u003cbr\u003eDetection of gene fusions and rearrangements\u003cbr\u003eDepending on the panel, RNA tumor profiling may detect fusions such as:\u003c\/p\u003e\u003cp\u003eALK fusions (e.g., EML4-ALK in lung cancer)\u003cbr\u003eROS1 fusions (lung cancer)\u003cbr\u003eRET fusions (lung, thyroid cancers)\u003cbr\u003eNTRK1\/2\/3 fusions (multiple solid tumors)\u003cbr\u003eFGFR fusions (bladder, cholangiocarcinoma)\u003cbr\u003eBCR-ABL1 fusion (CML – hematologic malignancy)\u003cbr\u003ePML-RARA fusion (acute promyelocytic leukemia)\u003cbr\u003eEWSR1 fusions (sarcomas)\u003c\/p\u003e\u003cp\u003eIdentification of actionable RNA biomarkers\u003cbr\u003eTumor classification and molecular subtyping\u003cbr\u003eTherapy selection (targeted therapy \u0026amp; immunotherapy)\u003cbr\u003eClinical trial matching\u003cbr\u003eComplementary analysis to DNA-based tumor profiling\u003c\/p\u003e","brand":"Enigma Genomics","offers":[{"title":"Default Title","offer_id":60790440558878,"sku":"EGCANRNA","price":4650.0,"currency_code":"SAR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0748\/6678\/6590\/files\/enigma-test-icon-oncology-ribbon-v1.png?v=1793570962","url":"https:\/\/shop.enigmagenomics.com\/en\/products\/egcanrna","provider":"Enigma Genomics","version":"1.0","type":"link"}