Y Chromosome Microdeletion

The Y Chromosome Microdeletion Test identifies small deletions in the azoospermia factor (AZF) regions of the Y chromosome (AZFa, AZFb, AZFc), which play a crucial role in sperm production. These deletions are a common genetic cause of male infertility, accounting for 5-15% of cases of non-obstructive azoospermia and severe oligospermia.

The test is performed using PCR-based methods to detect specific deletions within the AZF regions. Results provide valuable information about the potential for natural conception, the suitability of assisted reproductive techniques (e.g., ICSI), and the genetic implications for offspring. Genetic counseling is recommended for patients with confirmed Y chromosome microdeletions.

This test is essential for men experiencing infertility or poor sperm quality and supports personalized treatment and family planning decisions.