Comprehensive Renal Disease Panel

The Comprehensive Renal Disease Panel analyzes genes that are associated with renal disorders, including but not limited to Alport syndrome, focal segmental glomerulosclerosis (FSGS), nephrotic syndrome, renal tubular disorders, as well as syndromic conditions, which include renal disease or renal anomalies as a clinical feature. Renal disorders are genetically heterogeneous disorders representing a wide spectrum of hereditary renal conditions. The genetic heterogeneity associated with these renal conditions can make it difficult to use phenotype as the sole criterion to select a definitive cause. Broad panel testing allows for an efficient evaluation of several potential genes based on a single clinical indication. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant would also guide testing and diagnosis of at-risk relatives. Some genes in this test may be associated with additional disorders unrelated to this panel; such additional conditions are not included in the list of disorders tested.